Age-related differential growth rate and response to 4-hydroxynonenal in mouse aortic smooth muscle cells.

@article{Lee2006AgerelatedDG,
  title={Age-related differential growth rate and response to 4-hydroxynonenal in mouse aortic smooth muscle cells.},
  author={Tae-Jin Lee and Jung-Tae Lee and Sung-Kwon Moon and C -W Kim and Jong-Wook Park and Taeg Kyu Kwon},
  journal={International journal of molecular medicine},
  year={2006},
  volume={17 1},
  pages={
          29-35
        }
}
4-Hydroxynonenal (4-HNE) is a peroxidation product of omega-6-poly-unsaturated fatty acids and exerts growth modifying as well as cytotoxic activities. This aldehyde component of oxidized lipid is increased during the aging process. In this study, to characterize the potential role of the lipid peroxidation product in aging, we studied the effects of 4-HNE on cell proliferation and activation of cell-cycle machinery and the mitogen-activated protein kinase signaling pathway. 4-HNE-treated… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells.

Proceedings of the National Academy of Sciences of the United States of America • 2005

Serine proteases increase oxidative stress in lung cells.

American journal of physiology. Lung cellular and molecular physiology • 2001

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