Age-related differences in skeletal muscle insulin signaling: the role of stress kinases and heat shock proteins.

@article{Gupte2008AgerelatedDI,
  title={Age-related differences in skeletal muscle insulin signaling: the role of stress kinases and heat shock proteins.},
  author={Anisha A. Gupte and Gregory L. Bomhoff and Paige C Geiger},
  journal={Journal of applied physiology},
  year={2008},
  volume={105 3},
  pages={839-48}
}
Aging is associated with an increase in insulin resistance in skeletal muscle, yet the underlying mechanism is not well established. We hypothesize that with aging, a chronic increase in stress kinase activation, coupled with a decrease in oxidative capacity, leads to insulin resistance in skeletal muscle. In aged (24 mo old) and young (3 mo old) Fischer 344 rats, 2-deoxyglucose uptake and insulin signaling [as measured by phosphorylation of insulin receptor substrate-1 (IRS-1), Akt (protein… CONTINUE READING

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