Age-related differences in sensitivity to the antinociceptive effects of kappa opioids in adult male rats

@article{Smith2002AgerelatedDI,
  title={Age-related differences in sensitivity to the antinociceptive effects of kappa opioids in adult male rats},
  author={Mark A. Smith and Adam M. French},
  journal={Psychopharmacology},
  year={2002},
  volume={162},
  pages={255-264}
}
Abstract Rationale. Significant differences in the potency and effectiveness of opioid analgesics have been reported in subject populations differing in age. Although the relationship between aging and sensitivity to the antinociceptive effects of mu opioids has been examined extensively, relatively few studies have examined this relationship in kappa opioids. Objectives. The purpose of the present investigation was to examine the antinociceptive effects of selected kappa and mixed-action… CONTINUE READING

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