Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry.


Regional manual volumetry is the gold standard of in vivo neuroanatomy, but is labor-intensive, can be imperfectly reliable, and allows for measuring limited number of regions. Voxel-based morphometry (VBM) has perfect repeatability and assesses local structure across the whole brain. However, its anatomic validity is unclear, and with its increasing… (More)
DOI: 10.1016/j.neurobiolaging.2007.12.020


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