Age-related differences in neural activity during memory encoding and retrieval: a positron emission tomography study.

@article{Cabeza1997AgerelatedDI,
  title={Age-related differences in neural activity during memory encoding and retrieval: a positron emission tomography study.},
  author={Roberto Cabeza and Cheryl L. Grady and Lars Nyberg and Anthony R. McIntosh and Endel Tulving and Shitij Kapur and Joann M. Jennings and Sylvain Houle and F. I. M. Craik},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 1},
  pages={391-400}
}
Positron emission tomography (PET) was used to compare regional cerebral blood flow (rCBF) in young (mean 26 years) and old (mean 70 years) subjects while they were encoding, recognizing, and recalling word pairs. A multivariate partial-least-squares (PLS) analysis of the data was used to identify age-related neural changes associated with (1) encoding versus retrieval and (2) recognition versus recall. Young subjects showed higher activation than old subjects (1) in left prefrontal and… CONTINUE READING
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