Age-related deterioration of long-term potentiation in the CA3 and CA1 regions of hippocampal slices from the senescence-accelerated mouse.

@article{Katsuki1990AgerelatedDO,
  title={Age-related deterioration of long-term potentiation in the CA3 and CA1 regions of hippocampal slices from the senescence-accelerated mouse.},
  author={H. Katsuki and Kumatoshi Ishihara and Atsuyoshi Shimada and Toshio Takeda and Masamichi Satoh},
  journal={Archives of gerontology and geriatrics},
  year={1990},
  volume={11 1},
  pages={77-83}
}
Long-term potentiation (LTP) is one candidate for the mechanism underlying memory storage. In the present study, we carried out electrophysiological studies on hippocampal slices prepared from the senescence-accelerated mouse (SAM-P/8), a strain which shows accelerated senescence and failure of certain types of learning in behavioral tests. The findings were compared with those noted in the SAM-R/1 substrain without severe symptoms of senescence. No significant differences were found between… CONTINUE READING

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