Age-related deregulation of naive T cell homeostasis in elderly humans

  title={Age-related deregulation of naive T cell homeostasis in elderly humans},
  author={Sara Ferrando-Mart{\'i}nez and Ezequiel Ruiz-mateos and Ana Lilia Hern{\'a}ndez and Encarnaci{\'o}n Guti{\'e}rrez and Mar{\'i}a Del Mar Rodriguez-M{\'e}ndez and Antonio Ord{\'o}{\~n}ez and Manuel Leal},
Immunosenescence is characterized by phenotypic and functional changes of effector memory T cells. In spite of the well-described senescent defects of these experienced T cells, immune responses to new pathogens are also deeply affected in elderly humans, suggesting that naive T cells could also show age-related defects. It has been reported in both, animal models and humans, alterations of the naive T cell turnover associated to advanced age or low thymic function. However, as far as we know… CONTINUE READING


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