Age-related decrease in axonal transport measured by MR imaging in vivo

@article{Cross2008AgerelatedDI,
  title={Age-related decrease in axonal transport measured by MR imaging in vivo},
  author={Donna J. Cross and Jennifer A. Flexman and Yoshimi Anzai and Kenneth Maravilla and Satoshi Minoshima},
  journal={NeuroImage},
  year={2008},
  volume={39},
  pages={915-926}
}
Axonal transport is a crucial process for neuronal homeostasis and cell functions. In vitro studies have indicated transport rates decrease with age. Disruption of axonal transport has been implicated in age-associated neurodegenerative disorders. We hypothesized that aged rats would show decreased transport in the brain, which could be measured using in vivo manganese-enhanced MR imaging (Mn-MRI) and parametric estimation. Serial T1-weighted images were obtained at pre- and post-administration… CONTINUE READING

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