Age-related decline of presumptive inhibitory synapses in the sensorimotor cortex as revealed by the physical disector.

@article{Poe2001AgerelatedDO,
  title={Age-related decline of presumptive inhibitory synapses in the sensorimotor cortex as revealed by the physical disector.},
  author={Brandon Hollis Poe and Cole R Linville and Judy Karen Brunso-Bechtold},
  journal={The Journal of comparative neurology},
  year={2001},
  volume={439 1},
  pages={65-72}
}
The synapse, as the site of functional neural interaction, has been suggested as a possible substrate for age-related impairment of cognitive ability. Using the physical disector probe with tissue prepared for ultrastructural analysis, we find an age-related decline in the numerical density of presumptive inhibitory synapses in layer 2 of the sensorimotor cortex of the Brown Norway x Fisher 344 rat. This age-related decline in presumptive inhibitory synapses is maintained when the density of… CONTINUE READING