Age-related decline in label-retaining tubular cells: implication for reduced regenerative capacity after injury in the aging kidney.

@article{Miya2012AgerelatedDI,
  title={Age-related decline in label-retaining tubular cells: implication for reduced regenerative capacity after injury in the aging kidney.},
  author={Masaaki Miya and Akito Maeshima and Keiichiro Mishima and Noriyuki Sakurai and Hidekazu Ikeuchi and Takashi Kuroiwa and Keiju Hiromura and Yoshihisa Nojima},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={302 6},
  pages={
          F694-702
        }
}
Recovery after acute kidney injury is impaired in the elderly, but the precise mechanism for such age-related incompetence remains unclear. By in vivo bromodeoxyuridine (BrdU) labeling, renal progenitor cells (label-retaining cells; LRCs) were identified in tubules of normal rat kidney and were shown to be the origin of proliferating cells after injury. In the present study, the involvement of LRCs in the age-related decline of tubular recovery after injury was examined. After 1 wk of BrdU… 
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