Age-related decline in DNA repair function explains diminished ovarian reserve, earlier menopause, and possible oocyte vulnerability to chemotherapy in women with BRCA mutations.

@article{Oktay2014AgerelatedDI,
  title={Age-related decline in DNA repair function explains diminished ovarian reserve, earlier menopause, and possible oocyte vulnerability to chemotherapy in women with BRCA mutations.},
  author={Kutluk H Oktay and Fred Moy and Shiny Titus and Robert Stobezki and Volkan Turan and Maura N. Dickler and Sumanta K Goswami},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2014},
  volume={32 10},
  pages={1093-4}
}
United States are projected to increase by 27% based on population changes alone; if the cost of the initial and terminal years of care increase by 2% annually, this estimate increases to 39%. There are growing concerns among many—ranging from patients and their families to providers to payers and to policymakers—regarding these trends, their sustainability, and their ramifications. The high cost of newer anticancer drugs is certainly a contributor, but there are many other cost drivers as well… CONTINUE READING
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