Age-related changes of the functional architecture of the cortico-basal ganglia circuitry during motor task execution

@article{Marchand2011AgerelatedCO,
  title={Age-related changes of the functional architecture of the cortico-basal ganglia circuitry during motor task execution},
  author={William R. Marchand and James N. Lee and Yana Suchy and Cheryl Garn and Susanna Johnson and Nicole Wood and Gordon Chelune},
  journal={NeuroImage},
  year={2011},
  volume={55},
  pages={194-203}
}
Normal human aging is associated with declining motor control and function. It is thought that dysfunction of the cortico-basal ganglia circuitry may contribute to age-related sensorimotor impairment, however the underlying mechanisms are poorly characterized. The aim of this study was to enhance our understanding of age-related changes in the functional architecture of these circuits. Fifty-nine subjects, consisting of a young, middle and old group, were studied using functional MRI and a… CONTINUE READING

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