Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates.

  title={Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates.},
  author={Ettore Ferrari and Luca Cravello and B Muzzoni and D Casarotti and M Paltro and Sebastiano Bruno Solerte and Marisa Fioravanti and Giovanni Cuzzoni and Barbara Pontiggia and F Magri},
  journal={European journal of endocrinology},
  volume={144 4},
The aim of this review was to examine the evidence for age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in both physiological and pathological aging, on the basis of the many data in the literature, as well as of our personal findings. A statistically significant circadian rhythmicity of serum cortisol was maintained in elderly subjects, even if with a reduced amplitude of the 24 h fluctuations and a trend to an increase of the serum levels in the evening and at night-time… CONTINUE READING
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