Age-related changes of glutathione content, glucose transport and metabolism, and mitochondrial electron transfer function in mouse brain.

@article{Sasaki2001AgerelatedCO,
  title={Age-related changes of glutathione content, glucose transport and metabolism, and mitochondrial electron transfer function in mouse brain.},
  author={Toru Sasaki and Michio Senda and S Kim and Shuji Kojima and Akiko Kubodera},
  journal={Nuclear medicine and biology},
  year={2001},
  volume={28 1},
  pages={25-31}
}
To evaluate the oxidative stress-related parameters and to determine their order of appearance in the brain aging process, radionuclide experiments were carried out on male DBF1 mice at 3, 12, 24 and 30 months of age. The content of nonprotein sulfhydryl compounds, mainly glutathione, was estimated with technetium-99m meso-hexamethyl propyleneamine oxime ([99mTc]meso-HMPAO) tissue sampling. Glucose transport and metabolism was examined with [1-14C]2-deoxy-D-glucose (2-DG) tissue sampling… CONTINUE READING
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