Age-related changes of apoptotic cell death in human lymphocytes.

  title={Age-related changes of apoptotic cell death in human lymphocytes.},
  author={Katharina Schindowski and Silke Leutner and Walter E. M{\"u}ller and Anne Eckert},
  journal={Neurobiology of aging},
  volume={21 5},
Apoptosis seems to be involved in immunosenescence associated with aging. Moreover, in lymphocytes (PBL) of patients with Alzheimer's disease, an increased susceptibility to the apoptotic pathway has been described possibly due to impaired protection of oxidative stress. Accordingly, it seemed to be of particular interest to investigate the contribution of normal aging to the susceptibility from human lymphocytes to programmed cell death. We could show that PBL from elderly individuals (>60… CONTINUE READING