Age-related changes of DNA repair and mitochondrial DNA synthesis in the mouse brain

  title={Age-related changes of DNA repair and mitochondrial DNA synthesis in the mouse brain},
  author={Claudia Sofie Schmitz and Birgit Axmacher and Ulrike Zunker and Hubert Korr},
  journal={Acta Neuropathologica},
Using quantitative autoradiography, both nuclear DNA repair – measured as nuclear unscheduled DNA synthesis (UDS) – and mitochondrial (mt) DNA synthesis were evaluated in situ for several types of cells in the brains of untreated mice of various age. It was found that distinct types of neuronal cells showed a decline of both UDS and mtDNA synthesis with age, whereas – except for glial cells of the cerebral cortex – no glial or endothelial cells showed age-related alterations of UDS. Together… CONTINUE READING


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