Age-related changes in vascular sympathetic neurotransmission in the rat kidney.


The objective of this study was to determine the effects of aging on sympathetic neurotransmission in an important vascular resistance bed, the kidney. The experimental model utilized was the isolated perfused kidney from male Fischer 344 rats, 6, 12 and 24 months of age. Stimulus-induced (supramaximal V, 30 pulses, 1 msec) overflow of endogenous… (More)


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