Age-related changes in the susceptibility to clofibric acid, a hypolipidemic agent, of male rat liver.

Abstract

Age-related changes in the susceptibility to clofibric acid were investigated in male F344 rats of 8, 52, and 117 weeks old. Hepatomegaly, decrease of serum total cholesterol and triglyceride, increase of the total cytochrome P-450 contents, induction of the activities of microsomal omega-hydroxylation and peroxisomal beta-oxidation, proliferation of smooth endoplasmic reticulum and peroxisomes were detected in 8- and 52-week-old rats. In 117-week-old rats clofibric acid treatment resulted in decrease of serum total cholesterol, elevation of the activities of microsomal and peroxisomal enzymes, and slight proliferation of peroxisomes. These results suggest that the susceptibility of the male F344 rat liver to clofibric acid decreases in 117-week-old rats, though the effect is still recognizable.

Cite this paper

@article{Yamoto1995AgerelatedCI, title={Age-related changes in the susceptibility to clofibric acid, a hypolipidemic agent, of male rat liver.}, author={Takashi Yamoto and Yasuo Ohashi and Munehiro Teranishi and Masanori Takaoka and Sunao Manabe and Naochika Matsunuma and Tokutaro Makita}, journal={Toxicology letters}, year={1995}, volume={78 2}, pages={141-5} }