Age-related changes in the reactivity of the rat jejunum to cholinoceptor agonists.

@article{Kobashi1985AgerelatedCI,
  title={Age-related changes in the reactivity of the rat jejunum to cholinoceptor agonists.},
  author={Yeda Lucia Kobashi and Elisabete Pinto Breuing and Regina P Markus},
  journal={European journal of pharmacology},
  year={1985},
  volume={115 2-3},
  pages={
          133-8
        }
}
The contractile effects of barium, potassium, acetylcholine and acetyl-beta-methylcholine were studied in jejunum of 4, 12 and 20 month-old rats. The effects of age on the sensitivity and responsiveness of the jejunum to the agonists were examined using cumulative dose administration and measuring the pD2. The maximum contraction produced by the agonists and the sensitivity to barium and potassium were not modified by aging. In the middle-aged animals, the jejunum sensitivity to acetylcholine… CONTINUE READING
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