Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin.

@article{Carrino2003AgerelatedCI,
  title={Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin.},
  author={David A. Carrino and Patrik Onnerfjord and John D. Sandy and Gabriella Cs-Szab{\'o} and Paul G. Scott and Jessica Sorrell and Dick Heineg{\aa}rd and Arnold I Caplan},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 19},
  pages={17566-72}
}
Dramatic changes occur in skin as a function of age, including changes in morphology, physiology, and mechanical properties. Changes in extracellular matrix molecules also occur, and these changes likely contribute to the overall age-related changes in the physical properties of skin. The major proteoglycans detected in extracts of human skin are decorin and versican. In addition, adult human skin contains a truncated form of decorin, whereas fetal skin contains virtually undetectable levels of… CONTINUE READING

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