Age-related changes in the neuromuscular development of the internal anal sphincter.

@article{Nakano2008AgerelatedCI,
  title={Age-related changes in the neuromuscular development of the internal anal sphincter.},
  author={Reiji Nakano and Thambipillai Sri Paran and Udo Rolle and Prem Puri},
  journal={Journal of pediatric surgery},
  year={2008},
  volume={43 6},
  pages={1106-10}
}
PURPOSE The internal anal sphincter (IAS) plays an important role in the pathophysiology of constipation and incontinence. We hypothesized that functional bowel obstruction in premature infants is because of a poorly developed IAS. We investigated the neuromuscular development of IAS in fetal, newborn, and adolescent pigs. METHODS Paraffin sections of IAS from 5 different age groups, E60, E90, 1 day, 4, and 12 weeks old, were stained with protein gene product 9.5 (PGP9.5), *-smooth muscle… CONTINUE READING