Age-related changes in the endocannabinoid system in the mouse hippocampus.

  title={Age-related changes in the endocannabinoid system in the mouse hippocampus.},
  author={Anastasia Piyanova and Ermelinda Lomazzo and Laura Bindila and Raissa Lerner and Onder Albayram and Tim Ruhl and Beat Lutz and Andreas Zimmer and Andras Bilkei-Gorzo},
  journal={Mechanisms of ageing and development},
Previous studies have demonstrated that the endocannabinoid system significantly influences the progression of brain ageing, and the hippocampus is one of the brain regions most vulnerable to ageing and neurodegeneration. We have further examined age-related changes in the hippocampal endocannabinoid system by measuring the levels of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) in young and old mice from two different mouse strains. We found a decrease in 2-AG but not AEA levels in aged… CONTINUE READING
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