Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain

@article{Motte1989AgerelatedCI,
  title={Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain},
  author={Jacques Motte and R. Sanders Williams},
  journal={Acta Neuropathologica},
  year={1989},
  volume={77},
  pages={535-546}
}
Fifteen cases of Down syndrome between age 25–59 years were examined neuropathologically. A variety of histological methods were used to identify plaques and neurofibrillary tangles (NFT). All cases had some plaques or NFT, but their density was generally not high before the age of 40 years. Plaques and NFT tended to appear at about the same time although in somewhat different cortical areas. Changes appeared first in the dentate gyrus, subiculum, entorhinal and association neocortex. The… CONTINUE READING

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