Age-related changes in sensitivity of rat urinary bladder to autonomic agents.

@article{Kolta1984AgerelatedCI,
  title={Age-related changes in sensitivity of rat urinary bladder to autonomic agents.},
  author={Malak G Kolta and Lane J. Wallace and Michael C. Gerald},
  journal={Mechanisms of ageing and development},
  year={1984},
  volume={27 2},
  pages={183-8}
}
Experiments were done to determine if age-related changes occur in autonomic regulation of rat urinary bladder. The maximum contractile responses to acetylcholine were 63% and 15% greater in isolated bladders from 29-month and 17-month animals, respectively, as compared to 7-month animals. The amounts of [3H]quinuclidinyl benzilate bound to membrane preparations were 46% and 7% greater. In contrast, no age-related changes were observed in phenylephrine-induced contraction or in isoproterenol… CONTINUE READING