Age-related changes in renal cytochrome P-450 arachidonic acid metabolism in spontaneously hypertensive rats.

We recently demonstrated that renal synthesis of cytochrome P-450-dependent arachidonic acid (AA) metabolites is increased in spontaneously hypertensive rats (SHR) during the rapid elevation of blood pressure. In this study, the chemical identity of these metabolites is described, and the structural analysis together with differential susceptibility to… CONTINUE READING