Age-related changes in multiple neurotransmitter systems in the monkey brain.


Age-associated changes in cholinergic, monoaminergic and amino acid neurotransmitter systems were analyzed in 14 brain regions of 23 rhesus monkeys that ranged in age from 2 to 37 years. In the frontal pole, the levels of choline acetyltransferase (ChAT) activity, the density of [3H]ketanserin (serotonin type-2) binding sites and endogenous levels of dopamine, homovanillic acid and serotonin, all expressed per milligram of protein, decreased significantly with aging. In precentral motor cortex, ChAT activity decreased; in parietal and occipital cortex, the number of [3H]ketanserin binding sites decreased while the number of Na+-independent [3H]glutamate binding sites increased with age. In the caudate nucleus, endogenous levels of norepinephrine decreased. This descriptive study indicates that the aging monkey may be a very useful model for future investigations of age-associated transmitter abnormalities similar to those that occur in humans.

Citations per Year

2,191 Citations

Semantic Scholar estimates that this publication has 2,191 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Wenk1989AgerelatedCI, title={Age-related changes in multiple neurotransmitter systems in the monkey brain.}, author={Gary L. Wenk and Donald J Pierce and Robert G. Struble and Donald Price and Linda Collins Cork}, journal={Neurobiology of aging}, year={1989}, volume={10 1}, pages={11-9} }