Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow.

@article{Yu2011AgerelatedCI,
  title={Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow.},
  author={Ji Min Yu and Xiying Wu and Jeffrey M. Gimble and Xiaoyan Guan and Michael A. Freitas and Bruce A Bunnell},
  journal={Aging cell},
  year={2011},
  volume={10 1},
  pages={66-79}
}
The regeneration potential of mesenchymal stem cells (MSCs) diminishes with advanced age and this diminished potential is associated with changes in cellular functions. This study compared MSCs isolated from the bone marrow of rhesus monkeys (rBMSCs) in three age groups: young (< 5 years), middle (8-10 years), and old (> 12 years). The effects of aging on stem cell properties and indicators of stem cell fitness such as proliferation, differentiation, circadian rhythms, stress response proteins… CONTINUE READING

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