Age-related changes in iron homeostasis and cell death in the cerebellum of ceruloplasmin-deficient mice.

@article{Jeong2006AgerelatedCI,
  title={Age-related changes in iron homeostasis and cell death in the cerebellum of ceruloplasmin-deficient mice.},
  author={Suh Young Jeong and Samuel Paul David},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 38},
  pages={9810-9}
}
Iron is essential for a variety of cellular functions, but its levels and bioavailability must be tightly regulated because of its toxic redox activity. A number of transporters, binding proteins, reductases, and ferroxidases help maintain iron homeostasis to prevent cell damage. The multi-copper ferroxidase ceruloplasmin (Cp) converts toxic ferrous iron to its nontoxic ferric form and is required for iron efflux from cells. Absence of this enzyme in humans leads to iron accumulation and… CONTINUE READING

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Aceruloplasminemia

  • P Hahn, Y Qian, +4 authors JL Dunaief
  • Pediatr Res
  • 2004
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