Age-related changes in intracellular expression of IFN-γ and TNF-α in equine lymphocytes measured in bronchoalveolar lavage and peripheral blood.

@article{Hansen2013AgerelatedCI,
  title={Age-related changes in intracellular expression of IFN-γ and TNF-α in equine lymphocytes measured in bronchoalveolar lavage and peripheral blood.},
  author={Sanni Hansen and Lingshuang Sun and Keith Edward Baptiste and Julie Fjeldborg and David W. Horohov},
  journal={Developmental and comparative immunology},
  year={2013},
  volume={39 3},
  pages={228-33}
}
Diseases of the lower airways represent some of the most common conditions affecting horses of all ages, but the type and severity tends to follow the horses' age. The age-related dysregulation of pro-inflammatory cytokines may, in part contribute to the development of the diseases. Therefore, we hypothesize that the expression of pro-inflammatory cytokines increases with age. Peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage (BAL) cells from clinically healthy horses of… CONTINUE READING