Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys.

  title={Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys.},
  author={Nicholas M Kanaan and Jeffrey H. Kordower and Timothy J. Collier},
  journal={Neurobiology of aging},
  volume={31 6},
Aging remains the strongest risk factor for developing Parkinson's disease (PD), and there is selective vulnerability in midbrain dopamine (DA) neuron degeneration in PD. By tracking normal aging-related changes with an emphasis on regional specificity, factors involved in selective vulnerability and resistance to degeneration can be studied. Towards this end, we sought to determine whether age-related changes in microglia and astrocytes in rhesus monkeys are region-specific, suggestive of… CONTINUE READING


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