Age-related changes in electrophysiological responses to muscarinic receptor stimulation in rat myocardium.

@article{Su1995AgerelatedCI,
  title={Age-related changes in electrophysiological responses to muscarinic receptor stimulation in rat myocardium.},
  author={Na Su and Jianmin Duan and Margaret P. Moffat and Njanoor Narayanan},
  journal={Canadian journal of physiology and pharmacology},
  year={1995},
  volume={73 10},
  pages={1430-6}
}
Recent studies have demonstrated that the negative chronotropic and inotropic responses of the heart to cholinergic muscarinic receptor stimulation are strikingly enhanced with aging in the rat model. The present study investigated the electrophysiological basis of this phenomenon by determining the effects of a muscarinic receptor agonist, carbachol, on transmembrane action potential parameters in right atrial tissue and right ventricular free wall preparations from adult (6-8 months old) and… CONTINUE READING