Age-related changes in central effects of corticotropin-releasing factor (CRF) suggest a role for this mediator in aging anorexia and cachexia

@article{Tenk2017AgerelatedCI,
  title={Age-related changes in central effects of corticotropin-releasing factor (CRF) suggest a role for this mediator in aging anorexia and cachexia},
  author={Judit Tenk and Ildik{\'o} Rost{\'a}s and N{\'o}ra F{\"u}redi and Alexandra Mik{\'o} and Margit Solym{\'a}r and Szilvia So{\'o}s and Bal{\'a}zs Gaszner and Di{\'a}na Feller and Mikl{\'o}s Sz{\'e}kely and Erika P{\'e}terv{\'a}ri and M{\'a}rta Balask{\'o}},
  journal={GeroScience},
  year={2017},
  volume={39},
  pages={61-72}
}
Hypothalamic corticotropin-releasing factor (CRF) lays downstream to catabolic melanocortins and at least partly mediates their catabolic effects. Age-related changes in the melanocortin system (weak responsiveness in middle-aged and a strong one in old rats) have been shown to contribute to middle-aged obesity and later to aging anorexia and cachexia of old age groups. We hypothesized that catabolic (anorexigenic and hypermetabolic) CRF effects vary with aging similarly to those of… CONTINUE READING
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