Corpus ID: 13397319

Age-related changes in brain and pituitary 5 alpha-reductase with finasteride (Proscar) treatment.

  title={Age-related changes in brain and pituitary 5 alpha-reductase with finasteride (Proscar) treatment.},
  author={E. Lephart},
  journal={Neurobiology of aging},
  volume={16 4},
  • E. Lephart
  • Published 1995
  • Medicine
  • Neurobiology of aging
  • Finasteride (Proscar), a 5 alpha-reductase inhibitor, was administered with or without 5 alpha-dihydrotestosterone (DHT) in juvenile (28), peripubertal (48), or young adult (68-day-old) male rats. Luteinizing hormone (LH) levels and ventral prostate (VP) weights monitored the efficacy of the treatments. For each postnatal day tested, LH hormone levels were not significantly altered by finasteride, suggesting that 5 alpha-reductase inhibition does not modulate LH in male rats using this protocol… CONTINUE READING
    6 Citations


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