Age-related changes in body composition are associated with hepatic insulin resistance in conscious rats.

@article{Barzilai1996AgerelatedCI,
  title={Age-related changes in body composition are associated with hepatic insulin resistance in conscious rats.},
  author={Nir Barzilai and Luciano Rossetti},
  journal={The American journal of physiology},
  year={1996},
  volume={270 6 Pt 1},
  pages={E930-6}
}
Age-dependent changes in body composition and hepatic ([3H]glucose) glucose metabolism were examined in 2-, 4-, and 14-mo-old (n = 26) conscious Sprague-Dawley rats. Hepatic glucose production (HGP) and hepatic glucose-6-phosphatase maximum velocity were decreased 18 and 30%, respectively, between 2 and 4 mo but were unchanged with further aging. However, between 4 and 14 mo, twofold higher plasma insulin levels were required to maintain similar HGP, suggesting that hepatic insulin resistance… CONTINUE READING

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