Age-related changes in adenosine metabolic enzymes in sleep/wake regulatory areas of the brain.

@article{Mackiewicz2006AgerelatedCI,
  title={Age-related changes in adenosine metabolic enzymes in sleep/wake regulatory areas of the brain.},
  author={Miroslaw Mackiewicz and Elena V. Nikonova and John E Zimmermann and Micah A Romer and Jacqueline R Cater and Raymond J Galante and Allan I. Pack},
  journal={Neurobiology of aging},
  year={2006},
  volume={27 2},
  pages={351-60}
}
The impact of age on the enzymatic activities of adenosine metabolic enzymes, i.e., adenosine deaminase, adenosine kinase, cytosolic- and ecto-5'-nucleotidase have been assessed in the brain sleep/wake regulatory areas of young, intermediate and old rats (2, 12 and 24 months, respectively). There were significant spatial differences in the distribution of enzymes of adenosine metabolism in the brain. Age did not impact on the enzymatic activity of adenosine deaminase. Adenosine kinase activity… CONTINUE READING

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