Age-related changes in activation of mitogen-activated protein kinase cascades by oxidative stress.

@article{Guyton1998AgerelatedCI,
  title={Age-related changes in activation of mitogen-activated protein kinase cascades by oxidative stress.},
  author={Kathryn Z. Guyton and Myriam Gorospe and Xin Wang and Y D Mock and Gertrude C. Kokkonen and Ye Liu and George S. Roth and Nikki J. Holbrook},
  journal={The journal of investigative dermatology. Symposium proceedings},
  year={1998},
  volume={3 1},
  pages={23-7}
}
Oxidative stress is thought to play a critical role in aging and the pathogenesis of human disease. Molecular studies of both the physiologic function of oxidants and the deleterious consequences of exposure to oxidative stress have suggested that signal transduction cascades may be targeted by oxidants. Here, we review recent studies from this laboratory examining the molecular basis for the activation of mitogen-activated protein kinases by oxidative stress and the influence of these pathways… CONTINUE READING

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