Age-related change in the relationship between circadian period, circadian phase, and diurnal preference in humans

  title={Age-related change in the relationship between circadian period, circadian phase, and diurnal preference in humans},
  author={Jeanne F. Duffy and Charles A. Czeisler},
  journal={Neuroscience Letters},
Sleep and Aging: Circadian Influences
Sleep, circadian rhythms, and delayed phase in adolescence.
Circadian and homeostatic sleep-wake regulation in women : effects of age and major depressive disorder
Homeostatic and circadian aspects of sleep-wake regulation in young women suffering from a major depressive disorder with age-matched young healthy women and healthy older women under low and high sleep pressure under stringently controlled laboratory conditions is compared.
Aging of Intrinsic Circadian Rhythms and Sleep in a Diurnal Nonhuman Primate, Macaca mulatta
This first characterization of age-dependent changes in the intrinsic rhythms and sleep in rhesus monkeys, demonstrating major similarities to human aging phenotype, should assist in the search for the mechanisms involved and for effective prophylactic and therapeutic strategies.
Circadian rhythm sleep disorders.
The circadian rhythm syndromes included in the new International Classification of Sleep Disorders are reviewed as well as the most recent guidelines for diagnosis and treatment.


Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people.
An association between circadian phase, the relationship between the sleep-wake cycle and circadianphase, and morningness-eveningness in young adults is demonstrated and age-related changes in phase angle cannot be attributed fully to an age- related shift toward morningness.
Later endogenous circadian temperature nadir relative to an earlier wake time in older people.
It is hypothesized that under entrained conditions, these age-related changes in the relationship between circadian phase and wake time are likely associated with self-selected light exposure at an earlier circadian phase, which could account for the earlier clock hour to which the endogenous circadian pacemaker is entrained in older people and thereby further increase their propensity to awaken at an even earlier time.
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms
Age‐related decrements in sleep consolidation and increased susceptibility to circadian phase misalignment in older people appear to be related to the interaction between a reduction in the homeostatic drive for sleep and a reduced strength of the circadian signal promoting sleep in the early morning.
Association of intrinsic circadian period with morningness-eveningness, usual wake time, and circadian phase.
The biological basis of preferences for morning or evening activity patterns ("early birds" and "night owls") has been hypothesized but has remained elusive. The authors reported that, compared with
Stability, precision, and near-24-hour period of the human circadian pacemaker.
Estimation of the periods of the endogenous circadian rhythms of melatonin, core body temperature, and cortisol in healthy young and older individuals living in carefully controlled lighting conditions has revealed that the intrinsic period of the human circadian pacemaker averages 24.18 hours in both age groups, with a tight distribution consistent with other species.
Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans
  • D.G.M. Dijk, C. Czeisler
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
Analyses of the (nonadditive) interaction of the circadian and sleep-dependent components of sleep propensity and sleep structure revealed that the phase relation between the sleep-wake cycle and the circadian pacemaker during entrainment promotes the consolidation of sleep and wakefulness and facilitates the transitions between these vigilance states.
Human sleep: its duration and organization depend on its circadian phase.
Two- to threefold variations in sleep length were observed in 12 subjects living on self-selected schedules in an environment free of time cues. The duration of polygraphically recorded sleep
Age-Related Changes in Hamster Circadian Period, Entrainment, and Rhythm Splitting
The data are consistent with the observation that the circadian rhythm period of the male hamster shortens with age, and whether age influences the probability of rhythm splitting under prolonged constant light conditions.
Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle.
Exposure to bright light can indeed reset the human circadian pacemaker, which controls daily variations in physiologic, behavioral, and cognitive function, as indicated by recordings of body temperature and cortisol secretion.
The dependence of onset and duration of sleep on the circadian rhythm of rectal temperature
The sleep-wake cycle and the circadian rhythm of rectal temperature were recorded in subjects who lived singly in an isolation unit. In 10 subjects, the freerunning rhythms remained internally