Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice.

@article{SackmannSala2014AgerelatedAD,
  title={Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice.},
  author={Lucila Sackmann-Sala and Darlene E. Berryman and Ellen R. Lubbers and Han Zhang and Clare B. Vesel and Katie M. Troike and Elahu Gosney and Edward O. List and John J. Kopchick},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2014},
  volume={69 1},
  pages={34-43}
}
Growth hormone receptor-null (GHR(-/-)) mice are dwarf, insulin sensitive, and long-lived in spite of increased adiposity. However, their adiposity is not uniform, with select white adipose tissue (WAT) depots enlarged. To study WAT depot-specific effects on insulin sensitivity and life span, we analyzed individual WAT depots of 12- and 24-month-old GHR(-) (/-) and wild-type (WT) mice, as well as their plasma levels of selected hormones. Adipocyte sizes and plasma insulin, leptin, and… CONTINUE READING
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