Age-related alterations of gene expression patterns in human CD8+ T cells.

@article{Cao2010AgerelatedAO,
  title={Age-related alterations of gene expression patterns in human CD8+ T cells.},
  author={Jia-ning Cao and Sastry V. R. S. Gollapudi and Edward H Sharman and Zhenyu Jia and Sudhir Gupta},
  journal={Aging cell},
  year={2010},
  volume={9 1},
  pages={19-31}
}
Aging is associated with progressive T-cell deficiency and increased incidence of infections, cancer and autoimmunity. In this comprehensive study, we have compared the gene expression profiles in CD8+ T cells from aged and young healthy subjects using Affymetrix microarray Human Genome U133A-2 GeneChips. A total of 5.2% (754) of the genes analyzed had known functions and displayed statistically significant age-associated expression changes. These genes were involved in a broad array of complex… CONTINUE READING

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