Age-related alterations in noradrenergic neurotransmission in Sprague-Dawley and Fischer 344 rat strains

@article{Bickford2006AgerelatedAI,
  title={Age-related alterations in noradrenergic neurotransmission in Sprague-Dawley and Fischer 344 rat strains},
  author={Paula C Bickford},
  journal={AGE},
  year={2006},
  volume={6},
  pages={100-105}
}
This study compares the electrophysiological effects of locally applied norepinephrine and phencyclidine between 3 month old, 18.20 month old, and 24–26 month old Sprague-Dawley and Fischer 344 rats. Micro-pressure injection through multi-bareled micropipettes was used to apply drugs and record depressant effects on the discharge rate of single cerebellar Purkinje neurons. Neurons from the 3 month old animals were significantly more sensitive to locally applied norepinephrine and phencyclidine… CONTINUE READING