Age-related alterations in emotional behaviors and amygdalar corticotropin-releasing factor (CRF) and CRF-binding protein expression in aged Fischer 344 rats.

@article{Pisarska2000AgerelatedAI,
  title={Age-related alterations in emotional behaviors and amygdalar corticotropin-releasing factor (CRF) and CRF-binding protein expression in aged Fischer 344 rats.},
  author={Margareta Pisarska and J. Jeffrey Mulchahey and Jeffrey A. Welge and Thomas D. Geracioti and John W. Kasckow},
  journal={Brain research},
  year={2000},
  volume={877 2},
  pages={184-90}
}
Corticotropin-releasing factor (CRF) coordinates the mammalian response to stress. In the amygdala, the CRF system appears to be responsible, at least in part, for the behavioral responses resulting from stress. Associated with amygdalar CRF is a 37 kDa binding protein (CRF-BP) which may also play a role in regulating stressful stimuli. Aging has been shown to be associated with abnormal neuroendocrine stress systems and little is known with regards to how amygdalar stress systems change with… CONTINUE READING
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