Age-related alteration of poly(ADP-ribose) polymerase activity in different parts of the brain.

@article{Strosznajder2000AgerelatedAO,
  title={Age-related alteration of poly(ADP-ribose) polymerase activity in different parts of the brain.},
  author={Joanna Benigna Strosznajder and Henryk M Jęśko and Robert P Strosznajder},
  journal={Acta biochimica Polonica},
  year={2000},
  volume={47 2},
  pages={331-7}
}
Poly(ADP-ribose) polymerase (PARP) is a conserved enzyme involved in the regulation of DNA repair and genome stability. The role of PARP during aging is not well known. In this study PARP activity was investigated in nuclear fractions from hippocampus, cerebellum, and cerebral cortex of adult (4 months), old adult (14 months) and aged (24-27 months) rats. Concomitantly, the free radical evoked lipid peroxidation was estimated as thiobarbituric acid reactive substances (TBARS). The specific… CONTINUE READING

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