Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle.

@article{Marzetti2008AgerelatedAO,
  title={Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle.},
  author={Emanuele Marzetti and Stephanie Eva Wohlgemuth and Hazel Anne Lees and Hae Young Chung and Silvia Giovannini and Christiaan Leeuwenburgh},
  journal={Mechanisms of ageing and development},
  year={2008},
  volume={129 9},
  pages={542-9}
}
Mitochondria-mediated apoptosis represents a central process driving age-related muscle loss. However, the temporal relation between mitochondrial apoptotic signaling and sarcopenia as well as the regulation of release of pro-apoptotic factors from the mitochondria has not been elucidated. In this study, we investigated mitochondrial apoptotic signaling in skeletal muscle of rats across a wide age range. We also investigated whether mitochondrial-driven apoptosis was accompanied by changes in… CONTINUE READING

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