Age profile of immunity to influenza: effect of original antigenic sin.

  title={Age profile of immunity to influenza: effect of original antigenic sin.},
  author={Adam J. Kucharski and Julia R. Gog},
  journal={Theoretical population biology},
  volume={81 2},
When multiple infections are possible during an individual's lifetime, as with influenza, a host's history of infection and immunity will determine the result of future exposures. In turn, the suite of varying individual infection histories will shape the population level dynamics of the disease. Exploring the consequences of precisely how immunity is acquired using mathematical models has proven challenging though: if n strains have circulated previously, there are 2(n) combinations of past… CONTINUE READING

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