Age of onset and the prospectively observed course of illness in bipolar disorder.

@article{Coryell2013AgeOO,
  title={Age of onset and the prospectively observed course of illness in bipolar disorder.},
  author={William H. Coryell and Jess G Fiedorowicz and Andrew C. Leon and Jean M Endicott and Martin B. Keller},
  journal={Journal of affective disorders},
  year={2013},
  volume={146 1},
  pages={34-8}
}
BACKGROUND To test the validity of age-of-onset grouping in bipolar disorder through the use of prospectively observed time in mood episodes. METHODS Age-of-onset ranges from prior admixture analyses were used to divide 427 individuals with bipolar I or bipolar II disorders into early-, middle- and late- onset groups. These were compared by the proportions of weeks depressed and manic or hypomanic during a mean (SD) prospective follow-up of 17.4 (8.4) years. RESULTS As predicted, the group… CONTINUE READING
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