Age-of-asthma onset as a determinant of different asthma phenotypes in adults: a systematic review and meta-analysis of the literature

@article{Tan2015AgeofasthmaOA,
  title={Age-of-asthma onset as a determinant of different asthma phenotypes in adults: a systematic review and meta-analysis of the literature},
  author={Daniel J. Tan and Eugene Haydn Walters and Jennifer L. Perret and Caroline J. Lodge and Adrian J. Lowe and Melanie C Matheson and S. Dharmage},
  journal={Expert Review of Respiratory Medicine},
  year={2015},
  volume={9},
  pages={109 - 123}
}
Age-of-asthma onset is often used to distinguish different adult asthma phenotypes; however, similarities and differences between early- and late-onset adult asthma have not been summarized to date. Of the 2921 records found, we identified 12 studies comparing early- and late-onset current asthma in adults. Age 12 was most commonly used to delineate the two age-of-onset phenotypes. Adults with early-onset current asthma were more likely to be atopic and had a higher frequency of asthma attacks… 
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References

SHOWING 1-10 OF 71 REFERENCES
Asthma in adults: comparison of adult‐onset asthma with childhood‐onset asthma relapsing in adulthood
TLDR
It is indicated that subjects who did have childhood asthma and relapse in adulthood appeared to have a potentially more severe form of asthma.
Obesity and asthma: an association modified by age of asthma onset.
Severe asthma in adults.
  • S. Wenzel
  • Medicine, Biology
    American journal of respiratory and critical care medicine
  • 2005
TLDR
Treatment of severe asthma remains problematic, with corticosteroids remaining the most effective therapy, however, 5-lipoxygenase inhibitors, anti-IgE, and immunomodulatory drugs are also likely to have a place in treatment.
Predictors for the development of progressive severity in new-onset adult asthma.
Adult-onset asthma: is it really different?
TLDR
Understanding of the underlying mechanism of adult-onset asthma and identification of specific phenotypes may further the understanding of pathophysiology and treatment response, leading to better targeting of both existing and new approaches for personalised management.
Identifying adult asthma phenotypes using a clustering approach
TLDR
The aim of the present study was to identify distinct asthma phenotypes by applying latent class analysis (LCA), a model-based clustering method, to two large epidemiological studies, and revealed four distinct asthma Phenotypes in each sample.
Family History and the Risk of Early-Onset Persistent, Early-Onset Transient, and Late-Onset Asthma
TLDR
The results confirm earlier data that parental history of asthma and allergy is most strongly associated with early-onset persistent asthma and suggest that among genetically predisposed children, an early-life environmental exposure, maternal smoking during pregnancy, favors the development of early-ONSet asthma that persists into later early childhood.
Distinguishing adult-onset asthma from COPD: a review and a new approach
TLDR
The current management of chronic asthma in adults is based on achieving and maintaining control through step-up and step-down approaches, but further trials of back-titration in COPD are required before a similar approach can be endorsed.
Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection.
TLDR
The results suggest that C pneumoniae infection might promote the development of persistent airflow limitation in patients with nonatopic adult-onset asthma.
...
...