Age-matched comparison reveals early electrocardiography and echocardiography changes in dystrophin-deficient dogs.

@article{Fine2011AgematchedCR,
  title={Age-matched comparison reveals early electrocardiography and echocardiography changes in dystrophin-deficient dogs.},
  author={Deborah M. Fine and Jin-Hong Shin and Yongping Yue and Dietrich H Volkmann and Stacey Benton Leach and Bruce F. Smith and Mark A. McIntosh and Dongsheng Duan},
  journal={Neuromuscular disorders : NMD},
  year={2011},
  volume={21 7},
  pages={453-61}
}
The absence of dystrophin in the heart leads to Duchenne cardiomyopathy. Dystrophin-deficient dogs represent a critical model to translate novel therapies developed in mice to humans. Unfortunately, little is known about cardiophysiology changes in these dogs. We performed prospective electrocardiographic and echocardiographic examinations at 3, 6 and 12 months of age in four normal and three affected dogs obtained from the same litter. Affected dogs showed growth retardation and serum creatine… CONTINUE READING