Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice.

@article{Irvine2006AgeIA,
  title={Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice.},
  author={K A Irvine and William F Blakemore},
  journal={Journal of neuroimmunology},
  year={2006},
  volume={175 1-2},
  pages={69-76}
}
Axon loss is recognised as a significant contributor to the progression of the disability associated with multiple sclerosis. Although evidence of axon damage is found in areas of chronic demyelination it is more frequently seen in association with acute demyelination. This study compares the incidence of axon degeneration associated with the areas undergoing demyelination in young adult (8-10 weeks) and aged (6-7 months) C57BL/6 mice in cuprizone intoxication; a widely used model of… CONTINUE READING
36 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…