Age has a profound effect on the incidence and significance of chromosome abnormalities in myeloma

@article{Ross2005AgeHA,
  title={Age has a profound effect on the incidence and significance of chromosome abnormalities in myeloma},
  author={Fiona M. Ross and Ashraf Hamid Ibrahim and A Vilain-Holmes and Mark O. Winfield and Laura Chiecchio and Rebecca K M Protheroe and Paul Strike and J L Gunasekera and Anne Jones and Christine J Harrison and Gareth J Morgan and Nicholas C P Cross},
  journal={Leukemia},
  year={2005},
  volume={19},
  pages={1634-1642}
}
A simple high throughput micro-fluorescence in situ hybridisation technique (FISH) was used to detect chromosome 13 deletions (Δ13), immunoglobulin heavy chain (IgH) rearrangements, t(11;14)(q13;q32), t(4;14)(p16;q32), t(14;16)(q23;q32), p53 loss, and numerical changes of chromosomes 3, 6, 7, 9, 10, 11 and 17 in 228 cases of multiple myeloma (MM), including 33 asymptomatic/smouldering MM (SMM). The patients were not part of a clinical trial and were from 30 different hospitals. In all, 98.4% of… CONTINUE READING

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Challenges and Promises of Genetic Stratification of Risk in Multiple Myeloma.

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