Age-driven modulation of tRNA-derived fragments in Drosophila and their potential targets

  title={Age-driven modulation of tRNA-derived fragments in Drosophila and their potential targets},
  author={Spyros Karaiskos and Ammar S. Naqvi and Karl E. Swanson and Andrey Grigoriev},
  booktitle={Biology Direct},
Development of sequencing technologies and supporting computation enable discovery of small RNA molecules that previously escaped detection or were ignored due to low count numbers. While the focus in the analysis of small RNA libraries has been primarily on microRNAs (miRNAs), recent studies have reported findings of fragments of transfer RNAs (tRFs) across a range of organisms. Here we describe Drosophila melanogaster tRFs, which appear to have a number of structural and functional features… CONTINUE READING
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